Nothing wrong with it at all. Some very successful photographers shoot a wide range of different niches. Jeff Cable for example shoots weddings/events, portraits and sports including the Olympics. There is nothing wrong with having a wide ranging skill set.
Well your settings that you posted are definitely your #1 problem with your lens being the next problem. Your shutter speed is way to fast for low light. You need to let your sensor get enough light and to do that at night you need your shutter open much longer. For the sky or landscapes you’ll want it open for 20-30 seconds but you also need a tripod for this because movement will blur the photos. With the longer shutter you can then lower your ISO and reduce noise (grain).
For people or while shoothing hand held you’ll need a bit faster shutter. When hand heldThe R10 doesn’t have in body image stabilization (IBIS) so you’ll want to stick with at least a reciprocal of your focal length so at 45mm you’ll want to shoot more around 1/50 and I wouldn’t do more than 1/30 when hand held no matter your focal length. That is if you can shoot fairly steady hand held.
Your lens is really going to hold you back for low light stuff. For night you want a minimum of f2.8 or faster (lower number) aperture. I’m sure you’ve heard the term exposure triangle and your lens aperture is an important part of that. For example an f2.8 lens will let in twice the light of an f4 lens. It will allow you to use lower ISO and faster shutter for the same exposure.
Learn to use the exposure meter in your camera that looks something like this -3…2…1…0…1…2…3+ As you adjust the settings the little line under the numbers will move and show the current estimated exposure with the line needing to be centered for best exposure. That way you can see what the settings do to your exposure as you change them.