Can confirm from personal experience, KDE Plasma is arguably the best choice.
I used it on a tiny Surface Go without issue, and I use it with a touch pen display.
You can easily rearrange the UI so things are positioned where your hands are.
Also, it’s the only setup I found where I could rely on virtual keyboards alone, after installing OnBoard.
I also tried Gnome and PopOS, and Plasma came out on top.
Every earbud eventually causes friction bleeding or infection, given I wear them all day. But quality over ear headphones don’t have the same problem.
Also, I have the option to use a cord if I need to.