Probably…

Just because I’m a glutton for looking shit like this up, in 2011 the Cardinals played the Rams led by Sammy Sleeves, the Dream Team Eagles led by Mike Vick, the Niners led by Alex Smith, and then Sammy Sleeves again, so four in a row. Then they had Romo and then Alex Smith again, so five in six weeks. I’m sure there are other instances but this is just one that I found.

https://www.pro-football-reference.com/teams/crd/2011.htm

I wonder if there’s some sort of record for times in a season, they have Murray and Stafford in their division too